Peptide and Protein Synthesis by Solid-Phase Synthesis and Segment Condensation Approach with Oxime Resin.
نویسندگان
چکیده
منابع مشابه
single-step synthesis of multi-component spirobarbiturates using ionic liquids and synthesis of substituted pyridine filled with catalysts supported on solid substrate
in this thesis, a better reaction conditions for the synthesis of spirobarbiturates catalyzed by task-specific ionic liquid (2-hydroxy-n-(2-hydroxyethyl)-n,n-dimethylethanaminium formate), calcium hypochlorite ca(ocl)2 or n-bromosuccinimide (nbs) in the presence of water at room temperature by ultrasonic technique is provided. the design and synthesis of spirocycles is a challenging task becaus...
15 صفحه اولSolid-phase synthesis of cyclooctadepsipeptide N-4909 using a cyclization-cleavage method with oxime resin.
N-4909 (1), which has a stimulating activity on apolipoprotein E secretion in humanhepatoma Hep G2 cells, was isolated from the culture broth of Bacillus sp. No. 4691 by Hiramoto et al.l) This compound (1) was also isolated from Bacillus sp. A1238 as an inhibitor of acyl-CoA; cholesterol acyltransferase by Hasumi et al.2) This cyclooctadepsipeptide (1) and its diastereomer were synthesized for ...
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The feasibility of peptide synthesis by four component condensation (4CC) [1] has been demonstrated [2]. In particular the advantages of peptide synthesis by 4CC, namely coupling without carboxyl activation, the possibility of reaction in highly polar media, and the effectively unimolecular nature of the coupling step in such coupling of peptide fragments are being recognized [3]. The unique fe...
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Solid phase peptide synthesis method, which was introduced by Merrifield in 1963, has spawned the concept of combinatorial chemistry. In this review, we summarize the present technologies of solid phase peptide synthesis (SPPS) that are related to combinatorial chemistry. The conventional methods of peptide library synthesis on polymer support are parallel synthesis, split and mix synthesis and...
متن کاملSolid phase protein chemical synthesis.
The chemical synthesis of peptides or small proteins is often an important step in many research projects and has stimulated the development of numerous chemical methodologies. The aim of this review is to give a substantial overview of the solid phase methods developed for the production or purification of polypeptides. The solid phase peptide synthesis (SPPS) technique has facilitated conside...
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ژورنال
عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan
سال: 1994
ISSN: 0037-9980,1883-6526
DOI: 10.5059/yukigoseikyokaishi.52.370